Determining role of thymus in immune pathogenesis of autoimmune, oncological and infectious diseases

Research data presented in the article are based, mainly, on concept that thymus, together with bone marrow represent central organ of immune system being source all T cell populations that, following their migration from thymus to periphery, participate development response any antigens viral, bacterial and tissue origin, allergens. This difference is principal, as opposed which produces other members response, i.e., dendritic cells, macrophages, B cells. E.g., also generates cells migrate where they undergo differentiation Over last 50 years, a plethora was accumulated leading role pathogenesis virtually socially significant human diseases affecting modern mankind, including infectious malignant disorders, atherosclerosis, autoimmune allergic diseases. Moreover, current studies show aberrant functions different play these These disturbances peripheral areas organs proven develop, mainly thymic area. Hence, producing altered functional activities promote pathogenetic changes disorders. Currently, entire set immunotherapeutic approaches aimed for correction among same subpopulations at without taking into account mechanisms have induced before emigration thymus. One should, therefore, develop novel methods correct alterations within